Endocrine Abstracts

In vitro expanded antigen specific CD4+CD25+ regulatory T cells (Tregs), have been shown to suppress autoimmune diabetes, suggesting a novel approach to cellular immunotherapy for autoimmunity. However to interfere with ongoing disease requires at least 106 in vitro expanded antigen specific Tregs which are difficult to obtain from a polyclonal repertoire. Hence an alternative approach would be to instruct naïve or antigen specific CD4+T cells to ...